Parietal cell vagotomy is a relatively new operation. In recent years, there are bulky articles on this subject. Author carried out the gastric secretory response to insulin (0.5unit/kg) in total 13 mongrel dogs, 8 gastrostomized dogs and 5 parietal cell vagotomized dogs.
Insulin was given in all dogs at 1 month interval from 1st, 2nd and up to 3rd month. Each time after injection of insulin, gastric juice was obtained 8 times at 15 minute intervals for free acidity and total acidity.
1. In parietal cell vagotomy group, the mean values of free acidity after 1 month, 2 months, and 3 months of operation were 40.74%, 70.375x, 57.67% reductions respectively as compared with the value of control group, 37.88.73mEq/L. 2. In parietal cell vagotomy group, the mean values of insulin responded free acidity after I month, 2 months, and 3 months of operation revealed 76.740, 64.1061, 40.53% reductions respectively as compared with the value of control group, 64.5410.05 mEq/L.
3. In 1 month, 2 months, 3 months after parietal cell vagotomy, the values of P.A.OB.A.O were -10, +19.6, and +20.18mEq/L respectively. The values of I month and 2 months were Hollander test negative but 3 months was late positive.
4. The value of gastrin after 3 months of parietal cell vagotomy was 52.72Pg/ml which was 49.34% increase as compared with control group, 26.01Pg/ml.
5. So, parietal cell vagotomy is best operation with marked reduction of gastric acidity.
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